Partial Preparation of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione as a Potential Therapeutic Agent for the Treatment of Huntington’s Disease and Selected Cancers

Authors

Macy Sprunger, Olivet Nazarene UniversityFollow

Document Type

Article

First Advisor

Doug Armstrong

Publication Date

5-25-2017

Scholarship Domain(s)

Scholarship of Discovery

Abstract

We are proposing 1-anilino-8-(mercaptoamino)-1,8-octadione as a compound of potential pharmaceutical value. The addition of carbon disulfide to sodium trimethylsilanolate to yield a xanthate product has been analyzed and refined to a 70% yield. Several methods of aminating the xanthate product to yield a sulfenamide have been attempted and analyzed. Multiple attempts have been made to benzoylate the sulfenamide product with little success, with many concerns stemming from the unsuccessful amination reactions.

Comments

Honors Cohort 7. Graduation date 2017.

Recommended Citation

Sprunger, Macy, "Partial Preparation of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione as a Potential Therapeutic Agent for the Treatment of Huntington’s Disease and Selected Cancers" (2017). Honors Program Projects. 69.
https://digitalcommons.olivet.edu/honr_proj/69

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.