Presentation Title

Partial Preparation of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione as a potential Therapeutic Agent for the Treatment of Huntington’s Disease and Selected Cancers

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Event

Abstract

1-Anilino-8-(mercaptoamino)-1,8-octadione has been identified as a compound of pharmaceutical value. The addition of carbon disulfide to sodium trimethylsilanolate to yield a xanthate product has been analyzed and refined to a 70% yield. Several methods to aminate the xanthate product to yield a sulfenamide have been attempted and analyzed. Multiple attempts have been made to benzoylate the sulfenamide product with little success, with many concerns stemming from the unsuccessful amination reactions.

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Apr 18th, 5:30 PM

Partial Preparation of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione as a potential Therapeutic Agent for the Treatment of Huntington’s Disease and Selected Cancers

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1-Anilino-8-(mercaptoamino)-1,8-octadione has been identified as a compound of pharmaceutical value. The addition of carbon disulfide to sodium trimethylsilanolate to yield a xanthate product has been analyzed and refined to a 70% yield. Several methods to aminate the xanthate product to yield a sulfenamide have been attempted and analyzed. Multiple attempts have been made to benzoylate the sulfenamide product with little success, with many concerns stemming from the unsuccessful amination reactions.