Presentation Title

Partial Preparation of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione as a potential Therapeutic Agent for the Treatment of Huntington’s Disease and Selected Cancers

Location

Reed 330

Start Date

18-4-2017 5:30 PM

Description

1-Anilino-8-(mercaptoamino)-1,8-octadione has been identified as a compound of pharmaceutical value. The addition of carbon disulfide to sodium trimethylsilanolate to yield a xanthate product has been analyzed and refined to a 70% yield. Several methods to aminate the xanthate product to yield a sulfenamide have been attempted and analyzed. Multiple attempts have been made to benzoylate the sulfenamide product with little success, with many concerns stemming from the unsuccessful amination reactions.

Comments

Faculty Mentor: Dr. Douglas Armstrong

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Apr 18th, 5:30 PM

Partial Preparation of 1-Anilino-8-(Mercaptoamino)-1,8-Octadione as a potential Therapeutic Agent for the Treatment of Huntington’s Disease and Selected Cancers

Reed 330

1-Anilino-8-(mercaptoamino)-1,8-octadione has been identified as a compound of pharmaceutical value. The addition of carbon disulfide to sodium trimethylsilanolate to yield a xanthate product has been analyzed and refined to a 70% yield. Several methods to aminate the xanthate product to yield a sulfenamide have been attempted and analyzed. Multiple attempts have been made to benzoylate the sulfenamide product with little success, with many concerns stemming from the unsuccessful amination reactions.