Presentation Title

Synthesis, including microwave promotion, of selected cyclopropyl derivatives as stereochemically rigid probes of certain pharmalogical receptors

Location

Reed 330

Start Date

18-4-2017 5:50 PM

Description

The goal of my research is to synthesize a cyclopropyl compound using the Simmons-Smith reaction. This type of compound has a wide variety of potential uses as an anti-depressant, anti-histamine, analgesic, and in the treatments of obsessive compulsive disorder and anxiety. Many of the articles listed below examine the functions of cyclopropyl compounds structurally similar to my own. The compound I hope to synthesize will contain an acetoxy group, an amine group, and a phenyl group attached to the cyclopropyl ring. Similarities in structure often indicate a shared function in medicine, suggesting and supporting the possibilities of my compound being able to act as one of drugs listed above. Due to the steric rigidity (the cis and trans isomers) of my goal compound, and the fact that each isomer would exist as enantiomers, this makes four stereoisomers possible. I expect that each of the four may be useful as a “probe” for the receptors for several types of pharmacological activity, such as those listed above, and potentially others.

Comments

Faculty Mentor: Dr. Douglas Armstrong

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Apr 18th, 5:50 PM

Synthesis, including microwave promotion, of selected cyclopropyl derivatives as stereochemically rigid probes of certain pharmalogical receptors

Reed 330

The goal of my research is to synthesize a cyclopropyl compound using the Simmons-Smith reaction. This type of compound has a wide variety of potential uses as an anti-depressant, anti-histamine, analgesic, and in the treatments of obsessive compulsive disorder and anxiety. Many of the articles listed below examine the functions of cyclopropyl compounds structurally similar to my own. The compound I hope to synthesize will contain an acetoxy group, an amine group, and a phenyl group attached to the cyclopropyl ring. Similarities in structure often indicate a shared function in medicine, suggesting and supporting the possibilities of my compound being able to act as one of drugs listed above. Due to the steric rigidity (the cis and trans isomers) of my goal compound, and the fact that each isomer would exist as enantiomers, this makes four stereoisomers possible. I expect that each of the four may be useful as a “probe” for the receptors for several types of pharmacological activity, such as those listed above, and potentially others.