Document Type
Article
Publication Date
8-1-2004
Scholarship Domain(s)
Scholarship of Discovery
Abstract
Titanium-catalyzed hydroamination of 1,4- and 1,5-diynes by primary amines leads to imino-alkynes that undergo in situ 5-endo dig and 5-exo dig cyclization reactions, respectively. The products are 1,2,5-trisubstituted pyrroles accessed directly from readily available diyne starting materials.
Recommended Citation
Ramanathan, Balasubramanian, Adam J. Keith, Douglas Armstrong, and Adam L. Odom. "Pyrrole Syntheses Based on Titanium-Catalyzed Hydroamination of Diynes." Organic Letters 6.17 (2004): 2957-2960.
Comments
Reprinted with permission from Ramanathan, B., Keith, A. J., Armstrong, D., & Odom, A. L. (2004). Pyrrole syntheses based on titanium-catalyzed hydroamination of diynes. Organic Letters, 6(17): 2957-2960. Copyright 2004 American Chemical Society.