Presentation Title

Alpha Mangostin as a Chemoprotective Agent via Activation of the P53 Pathway for Breast Cancer

Faculty Mentor(s)

Dr. Gregory Long

Project Type

Honors Program project

Scholarship Domain(s)

Scholarship of Discovery

Presentation Type

Presentation

Abstract

Breast carcinoma is the most frequently diagnosed cancer among women and causes over 400,000 deaths yearly worldwide. Current treatments such as chemotherapy are not selective for cancerous tissues but are destructive to normal tissues as well. This causes a range of side effects including pain, nausea, hair loss, weakness, and more. Inactivation of p53 is an almost universal mutation within human cancer cells. The ability to activate the p53 pathway which protects cells from tumor formation is lost in 50% of cancers. Due to the prevalence of this mutation, p53 is a uniquely valuable target for applied research. Alpha mangostin has potential to be an effective p53 activator in which the small molecule disrupts the binding of p53 to MDMD, a negative regulator, causing the p53 cascade which results in cell cycle arrest for low level stressors. This protects the cells from Paclitaxel, a chemotherapy that only kills actively dividing cells.

Permission type

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

This document is currently not available here.

Share

COinS
 
Apr 10th, 2:00 PM Apr 10th, 2:20 PM

Alpha Mangostin as a Chemoprotective Agent via Activation of the P53 Pathway for Breast Cancer

Fishbowl

Breast carcinoma is the most frequently diagnosed cancer among women and causes over 400,000 deaths yearly worldwide. Current treatments such as chemotherapy are not selective for cancerous tissues but are destructive to normal tissues as well. This causes a range of side effects including pain, nausea, hair loss, weakness, and more. Inactivation of p53 is an almost universal mutation within human cancer cells. The ability to activate the p53 pathway which protects cells from tumor formation is lost in 50% of cancers. Due to the prevalence of this mutation, p53 is a uniquely valuable target for applied research. Alpha mangostin has potential to be an effective p53 activator in which the small molecule disrupts the binding of p53 to MDMD, a negative regulator, causing the p53 cascade which results in cell cycle arrest for low level stressors. This protects the cells from Paclitaxel, a chemotherapy that only kills actively dividing cells.