Faculty Mentor(s)
Dr. Douglas Armstrong
Project Type
Faculty Scholarship
Scholarship Domain(s)
Scholarship of Discovery
Presentation Type
Presentation
Abstract
Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there is a three-carbon separation, instead of two, and for some, whether a two-carbon separation or a three-carbon separation, there are two nitrogen atoms, instead of one oxygen atom and one nitrogen atom. Some (or all) of these latter cases could possibly be investigated later.
Permission Type
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Synthesis of Cyclopropyl Analogs of Stereochemically Rigid Probes of Certain Pharmacological Receptors
Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there is a three-carbon separation, instead of two, and for some, whether a two-carbon separation or a three-carbon separation, there are two nitrogen atoms, instead of one oxygen atom and one nitrogen atom. Some (or all) of these latter cases could possibly be investigated later.