Faculty Mentor(s)

Dr. Douglas Armstrong

Project Type

Faculty Scholarship

Scholarship Domain(s)

Scholarship of Discovery

Presentation Type

Presentation

Abstract

Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there is a three-carbon separation, instead of two, and for some, whether a two-carbon separation or a three-carbon separation, there are two nitrogen atoms, instead of one oxygen atom and one nitrogen atom. Some (or all) of these latter cases could possibly be investigated later.

Permission type

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Included in

Chemistry Commons

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Apr 17th, 4:00 PM Apr 17th, 4:20 PM

Synthesis of Cyclopropyl Analogs of Stereochemically Rigid Probes of Certain Pharmacological Receptors

Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there is a three-carbon separation, instead of two, and for some, whether a two-carbon separation or a three-carbon separation, there are two nitrogen atoms, instead of one oxygen atom and one nitrogen atom. Some (or all) of these latter cases could possibly be investigated later.